A crash during stage 4 between Villers-Cotterets and Joigny saw Xabier Zandio and Remy di Gregorio both out of the Tour de France. The fall occurred 70km into the 193km stage and also involved Euskaltel's Inigo Landaluze, who managed to finish the stage.
Zandio abandoned on the spot after breaking his collarbone while Di Gregorio finished the stage, but couldn't start stage 5 after it was found he had fractured his elbow. 21 year-old Di Grigorio will have to be operated on, according to his Française des Jeux team doctor Gerard Guillaume.
Zandio's absence will be a blow to Caisse d'Epargne, which is being led by yellow jersey contender Alejandro Valverde. Team manager Jose-Luis Jaimerena told AFP, "He's broken his right collarbone, it's impossible for him to carry on."
Zandio had also crashed on the first stage to Canterbury, but Jaimerena said: "It's nothing to do with that fall, he only took a knock on his right wrist there.
"But it's a big loss for the team. He's a rider who can work really hard for us no matter what the terrain."
(AFP contributed to this report)